Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.96 |
| ▸ | GAA | P10253 | 6/20 | 0.96 |
| ▸ | NPC1 | O15118 | 5/20 | 0.96 |
| ▸ | RAB9A | P51151 | 5/20 | 0.96 |
| ▸ | GLA | P06280 | 4/20 | 0.96 |
| ▸ | APP | P05067 | 12/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.84 |
| ▸ | TP53 | P04637 | 3/20 | 0.84 |
| ▸ | THRB | P10828 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.83 |
| ▸ | HPGD | P15428 | 3/20 | 0.83 |
| ▸ | PKM | P14618 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | POLB | P06746 | 3/20 | 0.75 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.75 |
| ▸ | CASP1 | P29466 | 1/20 | 0.75 |
| ▸ | CASP7 | P55210 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995933 | 0.98 | MAPT (1.00) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL5906538 | 0.92 | MAPT (1.00) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL3193978 | 0.92 | MAPT (0.81) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL13806256 | 0.92 | APP (1.00) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL31219254 | 0.92 | APP (1.00) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL3194266 | 0.91 | MAPT (1.00) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL2628259 | 0.91 | MAPT (0.86) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL2174265 | 0.90 | MAPT (0.78) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL5906664 | 0.87 | APP (0.84) | MAPTKDM4EGAANPC1RAB9A | |
| SCHEMBL17198993 | 0.87 | MAPT (0.74) | MAPTKDM4EGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416931-A1 | INHIBITORS OF POLYQ-AGGREGATION | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003015772-A1 | INHIBITORS OF POLYQ-AGGREGATION | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2003-02-27 | — | — | WO | disclosed |