Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592319 | 0.85 | TMEM97 (0.43) | SMN1; SMN2MEN1KMT2ANPSR1TMEM97 | |
| SCHEMBL5836154 | 0.85 | MEN1 (0.53) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL1949475 | 0.82 | HPGD (0.56) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL6323472 | 0.82 | MEN1 (0.48) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL4750456 | 0.80 | HDAC1 (0.50) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL31106295 | 0.80 | TMEM97 (0.39) | MEN1KMT2ANPSR1TMEM97SIGMAR1 | |
| SCHEMBL19946670 | 0.80 | TMEM97 (0.39) | MEN1KMT2ANPSR1TMEM97SIGMAR1 | |
| SCHEMBL3767269 | 0.80 | TMEM97 (0.47) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL1393916 | 0.80 | GABRP (0.39) | SMN1; SMN2ALDH1A1HRH1HRH3 | |
| SCHEMBL5592397 | 0.79 | TMEM97 (0.47) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111333627-B | Substituted 2-hydro-pyrazole derivatives as anticancer agents | 正大天晴药业集团股份有限公司 | 2024-09-13 | — | — | CN | disclosed |
| CN-111333627-A | Substituted 2-hydro-pyrazole derivatives as anti-cancer agents | 正大天晴药业集团股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-107428731-B | Substituted 2-hydro-pyrazole derivatives as anti-cancer agents | 正大天晴药业集团股份有限公司 | 2020-05-05 | — | — | CN | disclosed |
| US-9969719-B2 | Substituted 2-hydrogen-pyrazole derivative serving as anticancer drug | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-05-15 | — | — | US | disclosed |
| US-20180072707-A1 | SUBSTITUTED 2-HYDROGEN-PYRAZOLE DERIVATIVE SERVING AS ANTICANCER DRUG | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072707-A1 | SUBSTITUTED 2-HYDROGEN-PYRAZOLE DERIVATIVE SERVING AS ANTICANCER DRUG | CDK4, CDK6, CDK3 | SMN1; SMN2 2913/4885MEN1 3260/4885KMT2A 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.