Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960687 | 0.94 | GRM7 (0.55) | GRM7TSHRALDH1A1LMNARECQL | |
| SCHEMBL20165965 | 0.88 | GRM7 (0.46) | GRM7KCNH2SCN5ASCN9ATSHR | |
| SCHEMBL20165963 | 0.88 | GRM7 (0.46) | GRM7KCNH2SCN5ASCN9ATSHR | |
| SCHEMBL20165964 | 0.88 | GRM7 (0.46) | GRM7KCNH2SCN5ASCN9ATSHR | |
| SCHEMBL19960841 | 0.86 | GRM7 (0.49) | GRM7KCNH2SCN5ASCN9ALMNA | |
| SCHEMBL19960865 | 0.86 | GRM7 (0.51) | GRM7KCNH2SCN5ASCN9ATSHR | |
| SCHEMBL19960866 | 0.86 | GRM7 (0.51) | GRM7KCNH2SCN5ASCN9ATSHR | |
| SCHEMBL19960834 | 0.84 | GRM7 (0.45) | GRM7KCNH2SCN5ASCN9ALMNA | |
| SCHEMBL19953497 | 0.83 | GRM7 (0.55) | GRM7KCNH2SCN5ASCN9ATSHR | |
| SCHEMBL21542219 | 0.82 | GRM7 (0.51) | GRM7TSHRALDH1A1LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |