Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HPN | P05981 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30130048 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2HPNRAB9ANPC1CACNA1H | |
| SCHEMBL19964287 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2HPNRAB9ANPC1CACNA1H | |
| SCHEMBL19964551 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2HPNRAB9ANPC1CACNA1H | |
| SCHEMBL30469092 | 0.79 | KDM4A (0.54) | SMN1; SMN2RAB9ANPC1CACNA1HCACNA1B | |
| SCHEMBL25677972 | 0.79 | KDM4A (0.54) | SMN1; SMN2RAB9ANPC1CACNA1HCACNA1B | |
| SCHEMBL30920282 | 0.78 | CACNA1H (0.46) | SMN1; SMN2HPNGRM2RAB9ANPC1 | |
| SCHEMBL30920633 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2HPNGRM2RAB9ANPC1 | |
| SCHEMBL18664525 | 0.76 | GRM2 (0.57) | SMN1; SMN2GRM2HDAC1CTSSCTSK | |
| SCHEMBL30920900 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2HPNRAB9ANPC1CACNA1H | |
| SCHEMBL19249202 | 0.76 | GABRA1 (0.48) | SMN1; SMN2HPNKDM4AHDAC1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |