Sugi Predict

Sugi Predict / Compounds / SCHEMBL19964604

SCHEMBL19964604

SCHEMBL19964604

CCOC(=O)c1cc2c(B3OC(C)(C)C(C)(C)O3)ccn2c(C(C)=O)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ UCHL1 P09936 1/20 0.42
▸ ALDH1A1 P00352 5/20 0.38
▸ KDM4E B2RXH2 7/20 0.37
▸ NPSR1 Q6W5P4 2/20 0.37
▸ RXFP1 Q9HBX9 1/20 0.37
▸ GAA P10253 5/20 0.37
▸ HPGD P15428 3/20 0.37
▸ GLA P06280 2/20 0.37
▸ TSHR P16473 2/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ MAPK1 P28482 1/20 0.32
▸ NPC1 O15118 2/20 0.32
▸ POLB P06746 1/20 0.32
▸ CA12 O43570 2/20 0.32
▸ CA1 P00915 2/20 0.32
▸ CA2 P00918 2/20 0.32
▸ CA7 P43166 2/20 0.32
▸ CA9 Q16790 2/20 0.32
▸ CA14 Q9ULX7 2/20 0.32
▸ JAK2 O60674 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19964974 0.79 KDM4E (0.44) ALDH1A1KDM4ENPSR1RXFP1GAA
SCHEMBL19964435 0.77 UCHL1 (0.37) UCHL1ALDH1A1KDM4ENPSR1RXFP1
SCHEMBL19964413 0.77 KDM4E (0.48) ALDH1A1KDM4ENPSR1RXFP1GAA
SCHEMBL19964530 0.73 ALDH1A1 (0.46) ALDH1A1KDM4ENPSR1RXFP1GAA
SCHEMBL19964962 0.72 EED (0.38) ALDH1A1KDM4ENPSR1RXFP1GAA
SCHEMBL19599555 0.71 UCHL1 (0.46) UCHL1ALDH1A1GAATSHRHSD17B10
SCHEMBL21156134 0.71 KDM4E (0.47) ALDH1A1KDM4ENPSR1GAAHPGD
SCHEMBL24840045 0.70 UCHL1 (0.46) UCHL1ALDH1A1KDM4ERXFP1GAA
SCHEMBL30168056 0.70 UCHL1 (0.46) UCHL1ALDH1A1KDM4ERXFP1GAA
SCHEMBL12215764 0.70 TSHR (0.50) UCHL1ALDH1A1KDM4ETSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11661421-B2 Indolizine compounds, preparation method and use thereof HAIHE BIOPHARMA CO., LTD. (CN) 2023-05-30 — — US disclosed
US-11661421-B2 Indolizine compounds, preparation method and use thereof HAIHE BIOPHARMA CO., LTD. (CN) 2023-05-30 — — US disclosed
US-11661421-B2 Indolizine compounds, preparation method and use thereof HAIHE BIOPHARMA CO., LTD. (CN) 2023-05-30 — — US disclosed
CN-109790160-B Pyrido five-membered aromatic ring compound, preparation method and application thereof 上海海和药物研究开发股份有限公司 2022-11-15 — — CN disclosed
EP-3763712-B1 INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF HAIHE BIOPHARMA CO LTD (CN) 2021-11-24 — — EP disclosed
CN-110229151-B Indolizine compound, preparation method and application thereof 上海海和药物研究开发股份有限公司 2021-09-10 — — CN disclosed
US-10968215-B2 Pyrido five-element aromatic ring compound, preparation method therefor and use thereof SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) 2021-04-06 — — US disclosed
US-10968215-B2 Pyrido five-element aromatic ring compound, preparation method therefor and use thereof SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) 2021-04-06 — — US disclosed
EP-3763712-A1 INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF Shanghai Haihe Pharmaceutical Co., Ltd. (CN) 2021-01-13 — — EP disclosed
US-20200399270-A1 INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF HAIHE BIOPHARMA CO., LTD. (CN) 2020-12-24 — — US disclosed
US-20200399270-A1 INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF HAIHE BIOPHARMA CO., LTD. (CN) 2020-12-24 — — US disclosed
WO-2019170063-A1 INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF 上海海和药物研究开发有限公司 2019-09-12 — — WO disclosed
EP-3524602-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Haihe Pharmaceutical Co., Ltd. (CN) 2019-08-14 — — EP disclosed
EP-3524602-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Haihe Pharmaceutical Co., Ltd. (CN) 2019-08-14 — — EP disclosed
US-20190211010-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF HAIHE BIOPHARMA CO. LTD. (CN) 2019-07-11 — — US disclosed
US-20190211010-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF HAIHE BIOPHARMA CO. LTD. (CN) 2019-07-11 — — US disclosed
WO-2018045971-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 上海海和药物研究开发有限公司 2018-03-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11661421-B2 Indolizine compounds, preparation method and use thereof EZH1, EZH2, IKZF3 UCHL1 2736/4885ALDH1A1 2385/4885KDM4E 61/4885
US-10968215-B2 Pyrido five-element aromatic ring compound, preparation method therefor and use thereof EZH2, IKZF2, SUZ12 UCHL1 3711/4885ALDH1A1 2816/4885KDM4E 52/4885
US-20190211010-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF EZH2, IKZF2, SUZ12 UCHL1 3711/4885ALDH1A1 2816/4885KDM4E 52/4885
US-20200399270-A1 INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF EZH1, EZH2, IKZF3 UCHL1 2736/4885ALDH1A1 2385/4885KDM4E 61/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.