SCHEMBL19965486

SCHEMBL19965486

Cc1cc2c(c(F)c1C)CCC2C

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.30
HTR2C P28335 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL412687 0.71 UGT2B17 (0.56)
SCHEMBL14787806 0.69 HTR2C (0.39) HTR2AHTR2C
SCHEMBL20368645 0.68 HTR2A (0.44) HTR2AHTR2C
SCHEMBL18269911 0.68 ALDH1A1 (0.38)
SCHEMBL414118 0.67 KDM4E (0.42) HTR2C
SCHEMBL22144030 0.67 HTR2A (0.37) HTR2AHTR2C
SCHEMBL6967098 0.67 HTR2A (0.33) HTR2AHTR2C
SCHEMBL27431533 0.66 UGT2B17 (0.42)
SCHEMBL21803724 0.65 DRD2 (0.38)
SCHEMBL21803725 0.65 DRD2 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018049200-A1 PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER INCYTE CORPORATION (US) 2018-03-15 WO disclosed