Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.34 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.34 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12566371 | 0.97 | MAPT (0.51) | KMT2AMEN1MAPTCYP2D6TP53 | |
| Iodide SCHEMBL15855501 | 0.94 | LMNA (0.51) | KMT2AMEN1MAPTCYP2D6TP53 | |
| SCHEMBL12566375 | 0.85 | MAPT (0.43) | KMT2AMEN1MAPTCYP2D6TP53 | |
| Bromide SCHEMBL4769564 | 0.83 | KMT2A (0.72) | KMT2AMEN1MAPTCYP2D6TP53 | |
| Bromide SCHEMBL28044241 | 0.83 | KMT2A (0.72) | KMT2AMEN1MAPTCYP2D6TP53 | |
| Bromide SCHEMBL2868130 | 0.81 | KMT2A (0.75) | KMT2AMEN1MAPTCYP2D6TP53 | |
| Bromide SCHEMBL6224118 | 0.81 | KMT2A (0.75) | KMT2AMEN1MAPTCYP2D6TP53 | |
| Bromide SCHEMBL6024741 | 0.81 | KMT2A (0.75) | KMT2AMEN1MAPTCYP2D6TP53 | |
| Bromide SCHEMBL19664670 | 0.81 | KMT2A (0.75) | KMT2AMEN1MAPTCYP2D6TP53 | |
| Bromide SCHEMBL7141677 | 0.81 | KMT2A (0.75) | KMT2AMEN1MAPTCYP2D6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8773745-B2 | Electrochromic material | KYUSHU UNIVERSITY (JP) | 2014-07-08 | — | — | US | disclosed |
| US-20110149367-A1 | ELECTROCHROMIC MATERIAL | KYUSHU UNIVERSITY (JP) | 2011-06-23 | — | — | US | disclosed |