Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | ADH7 | P40394 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19818963 | 0.95 | HTT (0.49) | HTTCYP1A2KMT2AMEN1ADH1B | |
| SCHEMBL28996806 | 0.79 | CYP1A2 (0.41) | HTTCYP1A2KMT2AALDH1A1MEN1 | |
| SCHEMBL14810792 | 0.79 | HTT (0.46) | HTTCYP1A2ADH1BADH1CADH1A | |
| SCHEMBL172619 | 0.79 | HTT (0.46) | HTTCYP1A2ADH1BADH1CADH1A | |
| SCHEMBL10045069 | 0.77 | SAT1 (0.54) | HTTCYP1A2KMT2AMEN1ADH1B | |
| SCHEMBL21099705 | 0.77 | SIGMAR1 (0.47) | HTTKMT2AMEN1SIGMAR1 | |
| SCHEMBL8467849 | 0.77 | SIGMAR1 (0.47) | HTTKMT2AMEN1SIGMAR1 | |
| SCHEMBL28544175 | 0.76 | CYP1A2 (0.45) | HTTCYP1A2KMT2AALDH1A1MEN1 | |
| SCHEMBL19593153 | 0.74 | EPHX1 (0.41) | CYP1A2KMT2AMEN1ADH1BADH1C | |
| SCHEMBL11057091 | 0.74 | EPHX1 (0.41) | CYP1A2KMT2AMEN1ADH1BADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227340-B2 | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180072712-A1 | THIAZOLYL- OR THIADIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072712-A1 | THIAZOLYL- OR THIADIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | IRAK4, IRAK1, IRAK3 | HTT 4643/4885CYP1A2 4626/4885KMT2A 1241/4885 |
| US-10227340-B2 | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors | IRAK4, IRAK1, IRAK3 | HTT 4643/4885CYP1A2 4626/4885KMT2A 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.