⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24515158 | 0.87 | — | — | |
| SCHEMBL19966990 | 0.82 | — | — | |
| SCHEMBL25566785 | 0.78 | CYP2C19 (0.35) | — | |
| SCHEMBL13166556 | 0.78 | MEN1 (0.40) | — | |
| SCHEMBL19286534 | 0.74 | — | — | |
| SCHEMBL14176492 | 0.74 | CA12 (0.33) | — | |
| SCHEMBL21126648 | 0.74 | CYP2C9 (0.40) | — | |
| SCHEMBL2604979 | 0.74 | PRMT3 (0.48) | — | |
| SCHEMBL15467596 | 0.73 | CYP2C19 (0.38) | — | |
| Hydrochloric Acid SCHEMBL3176008 | 0.72 | PRMT3 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290419-B1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-08-07 | — | — | EP | disclosed |
| US-20180072704-A1 | Fused-Ring Or Tricyclic Aryl Pyrimidine Compound Used As Kinase Inhibitor | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-15 | — | — | US | disclosed |