Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15149972 | 0.80 | KDM1A (0.54) | KDM1ASLC6A3TAAR1HSD17B10CYP2A6 | |
| SCHEMBL22182753 | 0.80 | KDM1A (0.46) | KDM1ASLC6A3TP53TAAR1ALDH1A1 | |
| SCHEMBL10551347 | 0.79 | KDM1A (0.37) | KDM1AACHESLC6A3ALDH1A1MEN1 | |
| SCHEMBL18900047 | 0.77 | HRH3 (0.50) | ACHETAAR1ALDH1A1 | |
| SCHEMBL10550638 | 0.76 | SPHK1 (0.35) | KDM1ASLC6A3 | |
| SCHEMBL22703062 | 0.74 | HRH3 (0.53) | ACHETAAR1 | |
| SCHEMBL3673574 | 0.73 | HTR2A (0.52) | KDM1AACHESLC6A3ALDH1A1MAPT | |
| SCHEMBL23512612 | 0.73 | FFAR1 (0.60) | ALDH1A1 | |
| SCHEMBL23512759 | 0.73 | FFAR1 (0.60) | ALDH1A1 | |
| SCHEMBL1266510 | 0.72 | KDM1A (0.41) | KDM1ASLC6A3ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048762-A1 | INDAZOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-15 | — | — | WO | disclosed |