Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VSIR | Q9H7M9 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21168306 | 0.93 | KMT2A (0.36) | VSIRCD274CA2CA1MAPT | |
| SCHEMBL24058479 | 0.91 | VSIR (0.43) | VSIRCD274CA2CA1MAPT | |
| SCHEMBL21168304 | 0.90 | FOLH1 (0.42) | FOLH1 | |
| SCHEMBL20057150 | 0.90 | VSIR (0.36) | VSIRCD274TGFBR1MAPTKMT2A | |
| SCHEMBL21999116 | 0.89 | VSIR (0.36) | VSIRCD274CA2CA1MAPT | |
| SCHEMBL21168302 | 0.89 | FOLH1 (0.37) | VSIRCD274CA2CA1KMT2A | |
| SCHEMBL20057085 | 0.89 | VSIR (0.43) | VSIRCD274TGFBR1CA2CA1 | |
| SCHEMBL20057136 | 0.89 | VSIR (0.43) | VSIRCD274TGFBR1CA2CA1 | |
| SCHEMBL24058535 | 0.89 | VSIR (0.43) | VSIRCD274TGFBR1CA2CA1 | |
| SCHEMBL25477024 | 0.89 | VSIR (0.35) | VSIRCD274CA2CA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047139-A1 | COMPOUNDS AS MODULATORS OF TIGIT SIGNALLING PATHWAY | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-03-15 | — | — | WO | disclosed |