Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 9/20 | 0.52 |
| ▸ | CTSS | P25774 | 8/20 | 0.52 |
| ▸ | CTSB | P07858 | 4/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32676816 | 0.90 | KLK5 (0.59) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL2352344 | 0.85 | KLK5 (0.59) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL2352336 | 0.85 | KLK5 (0.59) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL30765043 | 0.85 | KLK5 (0.59) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL6491302 | 0.85 | KLK5 (0.59) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL29543144 | 0.85 | KLK5 (0.59) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL2346583 | 0.84 | CTSS (0.69) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL21946642 | 0.84 | CTSS (0.69) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL6680700 | 0.84 | KLK5 (0.61) | KLK5CTSKCTSSCTSBCTSL | |
| SCHEMBL4729306 | 0.84 | KLK5 (0.58) | KLK5CTSKCTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047139-A1 | COMPOUNDS AS MODULATORS OF TIGIT SIGNALLING PATHWAY | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-03-15 | — | — | WO | disclosed |