Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 16/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17176388 | 0.87 | HTR3A (0.58) | HTR3APKM | |
| SCHEMBL17170618 | 0.85 | HTR3A (0.56) | HTR3APKM | |
| SCHEMBL19969991 | 0.84 | HTR3A (0.56) | HTR3AKCNH2KMT2AL3MBTL1 | |
| SCHEMBL19068187 | 0.80 | HTR3A (0.59) | HTR3APKMKMT2AL3MBTL1 | |
| SCHEMBL19969961 | 0.76 | HTR3A (0.57) | HTR3AKCNH2KMT2AL3MBTL1 | |
| SCHEMBL17163651 | 0.73 | HTR3A (1.00) | HTR3A | |
| SCHEMBL17163738 | 0.73 | HTR3A (1.00) | HTR3A | |
| SCHEMBL19346266 | 0.72 | HTR3A (0.57) | HTR3APKMKCNH2 | |
| SCHEMBL19346255 | 0.72 | HTR3A (0.57) | HTR3AKCNH2KMT2A | |
| SCHEMBL17176437 | 0.72 | HTR3A (0.46) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072758-A1 | 5HT3 RECEPTOR ANTAGONISTS | TAKEDA CALIFORNIA, INC. | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072758-A1 | 5HT3 RECEPTOR ANTAGONISTS | HTR3A, HTR3B, HTR5A | HTR3A 1/4885PKM 2535/4885KCNH2 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.