Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730606 | 0.89 | USP2 (0.35) | TSHRUSP2 | |
| SCHEMBL18909689 | 0.87 | CA2 (0.41) | CA2MAPK1CA1GRIK1GRIK2 | |
| SCHEMBL19970160 | 0.86 | CA2 (0.39) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL25811458 | 0.84 | USP2 (0.32) | TSHRUSP2 | |
| SCHEMBL23315005 | 0.82 | CA2 (0.41) | CA2MAPK1CA1GRIK1SLC1A3 | |
| SCHEMBL20711871 | 0.81 | CA2 (0.41) | CA2MAPK1CA1GRIK1SLC1A2 | |
| SCHEMBL26575537 | 0.80 | HDAC1 (0.50) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL23314912 | 0.80 | TAS1R3 (0.33) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL21482210 | 0.79 | CA2 (0.43) | CA2GRIK1SLC1A2SLC1A1GRIK2 | |
| SCHEMBL22198721 | 0.79 | CA2 (0.43) | CA2GRIK1SLC1A2SLC1A1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3395814-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2022-04-06 | — | — | EP | disclosed |
| WO-2018049233-A9 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 4 IN COMBINATION WITH CYCLIN-DEPENDENT KINASE INHIBITORS | STRANSKY NICOLAS (US) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018049233-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR IN COMBINATION WITH CYCLIN-DEPENDENT KINASE INHIBITORS | STRANSKY NICOLAS (US) | 2018-03-15 | — | — | WO | disclosed |
| US-9234096-B2 | Color and heat stable polycarbonate compositions and methods of making | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-01-12 | — | — | US | disclosed |