Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19961241 | 0.83 | BDKRB1 (0.38) | USP30BACE1BACE2PRMT5WDR77 | |
| SCHEMBL19970261 | 0.81 | DRD2 (0.33) | DRD2 | |
| SCHEMBL19960760 | 0.80 | BACE1 (0.33) | USP30BACE1BACE2PRMT5WDR77 | |
| SCHEMBL19961239 | 0.80 | BACE1 (0.37) | USP30BACE1BACE2 | |
| SCHEMBL19949227 | 0.78 | ROCK1 (0.31) | — | |
| SCHEMBL19960730 | 0.77 | GAA (0.38) | USP30KDM4DEPHX2BTKBACE1 | |
| SCHEMBL19961244 | 0.77 | BDKRB1 (0.37) | USP30BACE1BACE2PRMT5WDR77 | |
| SCHEMBL4938767 | 0.76 | USP30 (0.44) | USP30EPHX2DRD2BACE1BACE2 | |
| SCHEMBL17549534 | 0.76 | USP30 (0.44) | USP30EPHX2DRD2BACE1BACE2 | |
| SCHEMBL19949203 | 0.74 | ESR2 (0.47) | USP30BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049152-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |