Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19970259 | 0.81 | USP30 (0.34) | DRD2 | |
| SCHEMBL19949227 | 0.78 | ROCK1 (0.31) | — | |
| SCHEMBL19948759 | 0.75 | HTR1D (0.35) | — | |
| SCHEMBL19950052 | 0.72 | CYP11B1 (0.30) | — | |
| SCHEMBL19961239 | 0.71 | BACE1 (0.37) | — | |
| SCHEMBL23962762 | 0.71 | DRD2 (0.37) | DRD2DRD4DRD3 | |
| SCHEMBL26426873 | 0.71 | DRD2 (0.37) | DRD2DRD4DRD3 | |
| SCHEMBL25218066 | 0.68 | — | — | |
| SCHEMBL26632115 | 0.67 | MAPK1 (0.33) | — | |
| SCHEMBL12078510 | 0.67 | MAPK1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049152-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |