Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.46 |
| ▸ | CTSS | P25774 | 6/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 4/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15804490 | 1.00 | CTSK (0.46) | CTSKCTSSTACR1KLK5CTSL | |
| SCHEMBL31725814 | 0.88 | TACR1 (0.54) | CTSKCTSSTACR1KLK5CTSL | |
| SCHEMBL15807614 | 0.88 | TACR1 (0.54) | CTSKCTSSTACR1KLK5CTSL | |
| SCHEMBL15792307 | 0.88 | TACR1 (0.54) | CTSKCTSSTACR1KLK5CTSL | |
| SCHEMBL15804392 | 0.88 | TACR1 (0.54) | CTSKCTSSTACR1KLK5CTSL | |
| SCHEMBL15802538 | 0.88 | CTSK (0.45) | CTSKCTSSTACR1CTSLTP53 | |
| SCHEMBL20644869 | 0.82 | MEN1 (0.41) | — | |
| SCHEMBL15804494 | 0.81 | CTSK (0.42) | CTSKCTSSTACR1KLK5CTSL | |
| SCHEMBL19983512 | 0.81 | MEN1 (0.41) | — | |
| SCHEMBL1336691 | 0.80 | CTSK (0.51) | CTSKCTSSTACR1KLK5CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3428153-A1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | Parion Sciences, Inc. (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-2931712-B1 | 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS | PARION SCIENCES INC (US) | 2018-03-21 | — | — | EP | disclosed |