Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GRK2 | P25098 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19971317 | 0.94 | TSHR (0.40) | TSHRBBOX1THRB | |
| SCHEMBL19971229 | 0.90 | BBOX1 (0.42) | TSHRBBOX1THRB | |
| SCHEMBL19971174 | 0.88 | TSHR (0.56) | TSHRBBOX1THRBENPP2EPHX2 | |
| SCHEMBL19971222 | 0.82 | TSHR (0.53) | TSHRBBOX1THRBENPP2EPHX2 | |
| SCHEMBL19971244 | 0.81 | BBOX1 (0.49) | TSHRBBOX1THRBMEN1LMNA | |
| SCHEMBL19971232 | 0.81 | TSHR (0.45) | TSHRBBOX1THRBEPHX2MEN1 | |
| SCHEMBL19971203 | 0.81 | TSHR (0.46) | TSHRBBOX1THRBPOLB | |
| SCHEMBL19971250 | 0.78 | TSHR (0.38) | TSHRTHRBMEN1LMNAPOLB | |
| SCHEMBL19971190 | 0.78 | TSHR (0.35) | TSHRBBOX1ENPP2EPHX2MEN1 | |
| SCHEMBL5972974 | 0.76 | TSHR (0.52) | TSHRBBOX1THRBENPP2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530286-B2 | Sulfobetaine-based protein aggregation inhibitor for use in preventing aggregation of a protein | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2022-12-20 | — | — | US | disclosed |
| US-10995160-B2 | Protein aggregation inhibitor | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2021-05-04 | — | — | US | disclosed |
| US-20200332044-A1 | PROTEIN AGGREGATION INHIBITOR | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2020-10-22 | — | — | US | disclosed |
| US-20180118859-A1 | PROTEIN AGGREGATION INHIBITOR | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
| EP-3296314-A1 | PROTEIN AGGREGATION INHIBITOR | Osaka Organic Chemical Industry Ltd. (JP) | 2018-03-21 | — | — | EP | disclosed |