Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19971174 | 0.95 | TSHR (0.56) | TSHRTHRBBBOX1POLBAPEX1 | |
| SCHEMBL19971203 | 0.90 | TSHR (0.46) | TSHRTHRBBBOX1POLBAPEX1 | |
| SCHEMBL19971317 | 0.88 | TSHR (0.40) | TSHRTHRBBBOX1 | |
| SCHEMBL16799129 | 0.85 | BBOX1 (0.47) | TSHRTHRBBBOX1POLBAPEX1 | |
| SCHEMBL19971230 | 0.82 | TSHR (0.43) | TSHRTHRBBBOX1POLBENPP2 | |
| SCHEMBL19971191 | 0.81 | TSHR (0.51) | TSHRTHRBBBOX1ALDH1A1EPHX2 | |
| SCHEMBL345585 | 0.81 | TSHR (0.53) | TSHRTHRBBBOX1POLBAPEX1 | |
| SCHEMBL16628613 | 0.81 | TSHR (0.53) | TSHRTHRBBBOX1POLBAPEX1 | |
| Lithium Ion SCHEMBL16628565 | 0.81 | TSHR (0.53) | TSHRTHRBBBOX1POLBAPEX1 | |
| SCHEMBL16628435 | 0.81 | TSHR (0.53) | TSHRTHRBBBOX1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530286-B2 | Sulfobetaine-based protein aggregation inhibitor for use in preventing aggregation of a protein | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2022-12-20 | — | — | US | disclosed |
| US-10995160-B2 | Protein aggregation inhibitor | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2021-05-04 | — | — | US | disclosed |
| US-20200332044-A1 | PROTEIN AGGREGATION INHIBITOR | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2020-10-22 | — | — | US | disclosed |
| US-20190161563-A1 | PROTEIN AGGREGATION INHIBITOR | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2019-05-30 | — | — | US | disclosed |
| US-20180118859-A1 | PROTEIN AGGREGATION INHIBITOR | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
| EP-3296314-A1 | PROTEIN AGGREGATION INHIBITOR | Osaka Organic Chemical Industry Ltd. (JP) | 2018-03-21 | — | — | EP | disclosed |