Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | SPNS2 | Q8IVW8 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1029841 | 0.88 | ALDH1A1 (0.53) | TLR8ALDH1A1POLBKMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL1029443 | 0.88 | ALDH1A1 (0.53) | TLR8ALDH1A1POLBKMT2AKCNH2 | |
| SCHEMBL1075831 | 0.86 | ALDH1A1 (0.54) | TLR8ALDH1A1POLBKMT2AKCNH2 | |
| SCHEMBL27627062 | 0.86 | TLR8 (0.51) | TLR8ALDH1A1POLBKMT2AKCNH2 | |
| Bromide SCHEMBL28272854 | 0.85 | TLR8 (0.55) | TLR8ALDH1A1POLBKMT2AKCNH2 | |
| SCHEMBL22356840 | 0.84 | TLR8 (0.49) | TLR8ALDH1A1POLBKMT2ACA12 | |
| SCHEMBL3865520 | 0.83 | TLR8 (0.53) | TLR8ALDH1A1POLBKMT2AKCNH2 | |
| SCHEMBL10532493 | 0.83 | TLR8 (0.53) | TLR8ALDH1A1POLBKMT2AKCNH2 | |
| SCHEMBL10530747 | 0.83 | TLR8 (0.53) | TLR8ALDH1A1POLBKMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL11091402 | 0.82 | TLR8 (0.53) | TLR8ALDH1A1POLBKMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512604-A1 | STABLE YELLOW IMIDAZOLIUM COMPOUNDS AND METHODS FOR THEIR USE | Noxell Corporation (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053027-A1 | STABLE YELLOW IMIDAZOLIUM COMPOUNDS AND METHODS FOR THEIR USE | NOXELL CORPORATION (US) | 2018-03-22 | — | — | WO | disclosed |