Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL19974416

C[C@@]1(CO)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N)nc(Cl)nc21.N

nearest known ligand 0.79

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 5/20 0.79
PDE4D Q08499 2/20 0.60
PDE3A Q14432 2/20 0.60
PNP P00491 1/20 0.60
LMNA P02545 1/20 0.60
TP53 P04637 1/20 0.60
HTT P42858 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
RXFP1 Q9HBX9 1/20 0.60
ADORA3 P0DMS8 10/20 0.59
ADORA1 P30542 4/20 0.59
PDE2A O00408 1/20 0.59
ADRA1A P35348 1/20 0.59
ADORA2B P29275 2/20 0.53
ADA P00813 1/20 0.53
ALOX15 P16050 1/20 0.53
HSP90AA1 P07900 1/20 0.51
HSP90B1 P14625 1/20 0.51
NT5E P21589 1/20 0.48
CA1 P00915 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29815502 1.00 ADORA2A (0.79) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL16480951 0.88 ADORA2A (0.80) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL28484259 0.88 ADORA2A (1.00) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL30262576 0.88 ADORA2A (1.00) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL3437025 0.88 ADORA2A (1.00) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL30262554 0.87 ADORA2A (0.79) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL19949236 0.87 ADORA2A (0.79) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL19974564 0.85 ADORA2A (0.58) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL19979035 0.85 ADORA2A (0.58) ADORA2APDE4DPDE3APNPLMNA
SCHEMBL19974427 0.84 ADORA2A (0.68) ADORA2APDE4DPDE3APNPLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3512860-B1 NUCLEOSIDE AND NUCLEOTIDE ANALOGUES BEARING A QUATERNARY ALL-CARBON STEREOGENIC CENTER AT THE 2' POSITION AND METHODS OF USE AS A CARDIOPROTECTIVE AGENT LCB PHARMA INC (CA) 2020-11-25 EP disclosed
EP-3512860-A1 NUCLEOSIDE AND NUCLEOTIDE ANALOGUES BEARING A QUATERNARY ALL-CARBON STEREOGENIC CENTER AT THE 2' POSITION AND METHODS OF USE AS A CARDIOPROTECTIVE AGENT LCB Pharma Inc. (CA) 2019-07-24 EP disclosed
WO-2018049534-A1 NUCLEOSIDE AND NUCLEOTIDE ANALOGUES BEARING A QUATERNARY ALL-CARBON STEREOGENIC CENTER AT THE 2' POSITION AND METHODS OF USE AS A CARDIOPROTECTIVE AGENT LCB PHARMA INC. (CA) 2018-03-22 WO disclosed