Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 14/20 | 0.65 |
| ▸ | MDM4 | O15151 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | IL2RA | P01589 | 1/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | IL2 | P60568 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974617 | 1.00 | YAP1 (0.65) | YAP1MDM4MDM2GAAIL2RA | |
| SCHEMBL19976383 | 0.91 | YAP1 (0.69) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19976384 | 0.91 | YAP1 (0.69) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19982219 | 0.87 | YAP1 (0.77) | YAP1MDM4MDM2IL2RAALB | |
| SCHEMBL19982220 | 0.87 | YAP1 (0.77) | YAP1MDM4MDM2IL2RAALB | |
| SCHEMBL19982184 | 0.86 | YAP1 (0.84) | YAP1MDM4MDM2GAAIL2RA | |
| SCHEMBL19982251 | 0.86 | YAP1 (0.84) | YAP1MDM4MDM2GAAIL2RA | |
| SCHEMBL19982077 | 0.84 | YAP1 (0.55) | YAP1MDM4MDM2GAAIL2RA | |
| SCHEMBL19982076 | 0.83 | YAP1 (0.54) | YAP1IL2RAALBIL2KMT2A | |
| SCHEMBL19982266 | 0.82 | YAP1 (0.79) | YAP1IL2RAALBIL2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |