Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 13/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | IL2RA | P01589 | 1/20 | 0.56 |
| ▸ | ALB | P02768 | 1/20 | 0.56 |
| ▸ | IL2 | P60568 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976383 | 1.00 | YAP1 (0.69) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19974618 | 0.91 | YAP1 (0.65) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19974617 | 0.91 | YAP1 (0.65) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19982213 | 0.87 | YAP1 (0.85) | YAP1GAAPOLB | |
| SCHEMBL19982212 | 0.87 | YAP1 (0.85) | YAP1GAAPOLB | |
| SCHEMBL19982177 | 0.85 | YAP1 (0.60) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19982135 | 0.84 | YAP1 (0.83) | YAP1GAAIL2RA | |
| SCHEMBL19982184 | 0.84 | YAP1 (0.84) | YAP1GAAIL2RA | |
| SCHEMBL19982179 | 0.84 | YAP1 (0.59) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19982251 | 0.84 | YAP1 (0.84) | YAP1GAAIL2RA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |