SCHEMBL19974697

SCHEMBL19974697

Cc1cccc(C(=O)NC(C)C(O)C(=O)NCC2CC2)c1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.52
F10 P00742 9/20 0.51
PRSS1 P07477 7/20 0.51
TAS1R3 Q7RTX0 1/20 0.47
TAS1R1 Q7RTX1 1/20 0.47
CTSL P07711 1/20 0.47
HPGD P15428 1/20 0.46
MAPK14 Q16539 1/20 0.46
USP2 O75604 1/20 0.46
F2 P00734 1/20 0.45
LMNA P02545 1/20 0.45
CCR2 P41597 1/20 0.45
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19975064 0.87 F10 (0.53) ATMF10PRSS1HPGDLMNA
SCHEMBL19975275 0.87 F10 (0.47) F10PRSS1CTSLMAPK14F2
SCHEMBL19975144 0.85 MAPK14 (0.49) F10PRSS1HPGDMAPK14NPC1
SCHEMBL28316681 0.85 F10 (0.53) F10PRSS1MAPK14F2
SCHEMBL19974729 0.82 ALDH1A1 (0.50) F10PRSS1CTSLMAPK14F2
SCHEMBL19975354 0.82 ALDH1A1 (0.53) F10PRSS1CTSLMAPK14LMNA
SCHEMBL21176167 0.81 ALDH1A1 (0.55) CTSLLMNA
SCHEMBL8297087 0.81 HPGD (0.65) ATMHPGDMAPK14CCR2NPC1
SCHEMBL19975288 0.80 ATM (0.53) ATMF10PRSS1TAS1R3TAS1R1
SCHEMBL28315914 0.80 F10 (0.47) F10PRSS1MAPK14F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220356148-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2022-11-10 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
EP-3512836-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2019-07-24 EP disclosed
WO-2018050631-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225575-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G12A, PLA2G4C ATM 4579/4885F10 1167/4885PRSS1 347/4885
US-20220356148-A1 ANTIVIRAL COMPOUNDS PLA2G12A, PLA2G1B, PLA2G4C ATM 4543/4885F10 1141/4885PRSS1 433/4885
US-11091428-B2 Antiviral compounds PLA2G1B, PLA2G12A, PLA2G4C ATM 4579/4885F10 1167/4885PRSS1 347/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.