Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 12/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19975035 | 1.00 | YAP1 (0.62) | YAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19982080 | 0.89 | YAP1 (0.76) | YAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19982125 | 0.85 | YAP1 (0.57) | YAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19974621 | 0.81 | YAP1 (0.63) | YAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19974620 | 0.81 | YAP1 (0.63) | YAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19982082 | 0.79 | YAP1 (0.62) | YAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19982150 | 0.79 | YAP1 (0.62) | YAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL16552342 | 0.79 | PPARG (0.69) | YAP1PPARGALDH1A1MEN1LMNA | |
| SCHEMBL19982058 | 0.78 | YAP1 (0.77) | YAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19982135 | 0.78 | YAP1 (0.83) | YAP1PPARGGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |