SCHEMBL19975441

SCHEMBL19975441

CC(C)N(C=O)C(C)C(=O)C(=O)NC(C)(C)c1cccc(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP36 Q9P275 1/20 0.41
SLC6A2 P23975 2/20 0.36
CHRNA1 P02708 1/20 0.36
CHRNG P07510 1/20 0.36
ITGA5 P08648 1/20 0.36
CHRNB1 P11230 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
SLC6A4 P31645 1/20 0.36
CHRNA3 P32297 1/20 0.36
CYP2C19 P33261 1/20 0.36
HRH1 P35367 1/20 0.36
CHRNA7 P36544 1/20 0.36
OPRK1 P41145 1/20 0.36
CHRNA4 P43681 1/20 0.36
SLC6A3 Q01959 1/20 0.36
CHRND Q07001 1/20 0.36
KCNH2 Q12809 1/20 0.36
MDM2 Q00987 3/20 0.36
ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19974769 0.81 USP36 (0.40) USP36SLC6A2CHRNA1CHRNGITGA5
SCHEMBL19975185 0.80 GAA (0.37) USP36SLC6A2CHRNA1CHRNGITGA5
SCHEMBL19974691 0.78 USP36 (0.36) USP36SLC6A2CHRNA1CHRNGITGA5
SCHEMBL19975432 0.75 GABRP (0.43) GAA
SCHEMBL20738625 0.71 USP36 (0.49) USP36SLC6A2CHRNA1CHRNGITGA5
SCHEMBL3677265 0.71 USP36 (0.49) USP36SLC6A2CHRNA1CHRNGITGA5
SCHEMBL19975545 0.68 USP36 (0.47) USP36SLC6A2CHRNA1CHRNGITGA5
SCHEMBL9150369 0.66 SLC6A2 (0.51) USP36SLC6A2CHRNA1CHRNGITGA5
SCHEMBL21176186 0.66 GAA (0.37) USP36SLC6A2CHRNA1CHRNGITGA5
SCHEMBL11534074 0.66 MEN1 (0.50) USP36ALDH1A1SMN1; SMN2GAAVNN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220356148-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2022-11-10 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
EP-3512836-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2019-07-24 EP disclosed
WO-2018050631-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225575-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G12A, PLA2G4C USP36 2078/4885SLC6A2 3243/4885CHRNA1 3193/4885
US-20220356148-A1 ANTIVIRAL COMPOUNDS PLA2G12A, PLA2G1B, PLA2G4C USP36 2638/4885SLC6A2 3542/4885CHRNA1 3607/4885
US-11091428-B2 Antiviral compounds PLA2G1B, PLA2G12A, PLA2G4C USP36 2078/4885SLC6A2 3243/4885CHRNA1 3193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.