Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 0.65 |
| ▸ | MMP2 | P08253 | 8/20 | 0.65 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28353475 | 0.79 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL17871364 | 0.79 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL17871443 | 0.76 | ADAMTS5 (0.58) | ADAMTS5MMP2MMP14 | |
| SCHEMBL17871085 | 0.68 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL17871544 | 0.67 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL17871483 | 0.66 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL17871442 | 0.66 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP14ADAM17 | |
| SCHEMBL19759026 | 0.65 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL17871124 | 0.65 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL17871497 | 0.65 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP14ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926281-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | GALAPAGOS NV (BE) | 2018-03-27 | — | — | US | disclosed |