Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | CA1 | P00915 | 6/20 | 0.45 |
| ▸ | CA2 | P00918 | 6/20 | 0.45 |
| ▸ | CA4 | P22748 | 6/20 | 0.45 |
| ▸ | CA5A | P35218 | 6/20 | 0.45 |
| ▸ | CA7 | P43166 | 6/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.45 |
| ▸ | CA6 | P23280 | 4/20 | 0.45 |
| ▸ | CA9 | Q16790 | 4/20 | 0.45 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10148601 | 0.95 | TSHR (0.59) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL19976436 | 0.95 | TSHR (0.59) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL19976435 | 0.95 | TSHR (0.62) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL24378390 | 0.91 | TSHR (0.50) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL20281028 | 0.91 | TSHR (0.50) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL27300740 | 0.91 | TSHR (0.50) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL12308089 | 0.89 | TSHR (0.50) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL17502004 | 0.88 | TSHR (0.59) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL17501989 | 0.88 | LMNA (0.60) | TSHRLMNAALDH1A1CYP2D6MAPK1 | |
| SCHEMBL20306742 | 0.88 | NT5E (0.51) | TSHRPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9919055-B2 | Sugar-linker-drug conjugates | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2018-03-20 | — | — | US | disclosed |