Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 8/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976858 | 0.91 | MAPK1 (0.46) | MAPK1FGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL19976764 | 0.90 | GSK3B (0.48) | MAPK1FGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL19976768 | 0.89 | MAPK1 (0.38) | MAPK1FGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL19976812 | 0.88 | GSK3B (0.51) | MAPK1FGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL19976815 | 0.88 | GSK3B (0.44) | MAPK1HDAC6GSK3BNTRK1PLK4 | |
| SCHEMBL19976757 | 0.85 | HDAC6 (0.39) | HDAC6GSK3BABL1BCRCYP1A2 | |
| SCHEMBL19976782 | 0.85 | MAPK1 (0.36) | MAPK1FGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL19976828 | 0.84 | GSK3B (0.49) | MAPK1FGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL19976805 | 0.84 | ALDH1A1 (0.36) | MAPK1SMN1; SMN2GSK3BABL1BCR | |
| SCHEMBL19976846 | 0.84 | KDM4E (0.42) | MAPK1HDAC6KDM4EGSK3BABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |