Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21650049 | 1.00 | HDAC4 (0.40) | HDAC4HDAC1 | |
| SCHEMBL19943418 | 1.00 | HDAC4 (0.40) | HDAC4HDAC1 | |
| SCHEMBL24590922 | 0.93 | HDAC4 (0.44) | HDAC4HDAC1 | |
| SCHEMBL24590889 | 0.92 | HDAC4 (0.44) | HDAC4HDAC1 | |
| SCHEMBL24590858 | 0.91 | HDAC4 (0.43) | HDAC4HDAC1 | |
| SCHEMBL20611641 | 0.90 | HDAC4 (0.45) | HDAC4HDAC1 | |
| SCHEMBL19819244 | 0.90 | HDAC4 (0.45) | HDAC4HDAC1 | |
| SCHEMBL20611590 | 0.90 | HDAC4 (0.45) | HDAC4HDAC1 | |
| SCHEMBL19943404 | 0.90 | HDAC4 (0.45) | HDAC4HDAC1 | |
| SCHEMBL20611440 | 0.90 | HDAC4 (0.45) | HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822377-B2 | Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-11-03 | — | — | US | disclosed |
| US-10570179-B2 | Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-02-25 | — | — | US | disclosed |
| US-20200031872-A1 | Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase | ST. JUDE CHILDREN'S RESEARCH HOSPITAL | 2020-01-30 | — | — | US | disclosed |
| US-10457707-B2 | Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2019-10-29 | — | — | US | disclosed |
| US-20190185517-A1 | SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2019-06-20 | — | — | US | disclosed |
| US-20190048040-A1 | Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase | ST JUDE CHILDRENS RES HOSPITAL (US) | 2019-02-14 | — | — | US | disclosed |
| US-20180079784-A1 | Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase | ST.JUDE CHILDREN'S RESEARCH HOSPITAL | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570179-B2 | Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase | CLPP, DNPEP, PEPD | HDAC4 1924/4885HDAC1 1762/4885 |
| US-10457707-B2 | Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase | CLPP, DNPEP, PEPD | HDAC4 1924/4885HDAC1 1762/4885 |
| US-20180079784-A1 | Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase | CLPP, PEPD, DNPEP | HDAC4 2000/4885HDAC1 1861/4885 |
| US-10822377-B2 | Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase | CLPP, DNPEP, PEPD | HDAC4 1924/4885HDAC1 1762/4885 |
| US-20190185517-A1 | SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE | CLPP, DNPEP, PEPD | HDAC4 1924/4885HDAC1 1762/4885 |
| US-20190048040-A1 | Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase | CLPP, DNPEP, PEPD | HDAC4 1924/4885HDAC1 1762/4885 |
| US-20200031872-A1 | Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase | CLPP, DNPEP, PEPD | HDAC4 1924/4885HDAC1 1762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.