Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.48 |
| ▸ | BRD4 | O60885 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | NAT1 | P18440 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531362 | 0.82 | CREBBP (0.40) | CREBBPBRD4PARP1PARP10PARP11 | |
| SCHEMBL1851941 | 0.76 | CREBBP (0.58) | CREBBPBRD4PARP1CDK5CDK5R1 | |
| SCHEMBL15964658 | 0.73 | CREBBP (0.55) | CREBBPBRD4GRIA1CACNG8CDK5 | |
| SCHEMBL14425325 | 0.70 | HTR5A (0.44) | CREBBPBRD4POLBAKR1B1PARP1 | |
| SCHEMBL17321229 | 0.70 | CREBBP (0.48) | CREBBPBRD4PARP1GRIA1CACNG8 | |
| SCHEMBL31170723 | 0.68 | ALDH1A1 (0.44) | CREBBPBRD4PARP1PARP10PARP11 | |
| SCHEMBL4898912 | 0.68 | ALDH1A1 (0.44) | CREBBPBRD4PARP1PARP10PARP11 | |
| SCHEMBL10558622 | 0.68 | CREBBP (0.47) | CREBBPBRD4POLBAKR1B1CA1 | |
| SCHEMBL19746612 | 0.66 | BRD4 (0.36) | CREBBPBRD4PARP1PARP10PARP11 | |
| SCHEMBL17680581 | 0.65 | CREBBP (1.00) | CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |