Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 7/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294115 | 0.85 | HDAC8 (0.55) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL25041715 | 0.81 | NR1H4 (0.51) | HDAC8HDAC6HTTSMN1; SMN2EPHX2 | |
| SCHEMBL16504240 | 0.80 | HDAC8 (0.50) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL19707372 | 0.79 | MAPT (0.47) | HPGDSMN1; SMN2KIF11 | |
| SCHEMBL1646972 | 0.78 | NAPRT (0.46) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL28822065 | 0.77 | POLB (0.41) | HPGDTSHRHTTSMN1; SMN2CA2 | |
| SCHEMBL28130554 | 0.77 | MAPT (0.49) | HPGDHTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL3374091 | 0.77 | POLB (0.58) | TSHRHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL250247 | 0.77 | HDAC6 (0.80) | HDAC8HDAC6HDAC2HPGDTSHR | |
| Hydrochloric Acid SCHEMBL8791650 | 0.76 | NAPRT (0.45) | HDAC8HDAC6HDAC2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2538785-B1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS LLC (US) | 2018-03-21 | — | — | EP | disclosed |