Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PPARD | Q03181 | 3/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5468286 | 0.81 | MAPT (0.54) | MAPTMAPK1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL28179876 | 0.78 | MAPT (0.55) | MAPTMAPK1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL19980084 | 0.78 | MAPT (0.55) | MAPTMAPK1NPSR1KDM4EKMT2A | |
| SCHEMBL22048143 | 0.76 | KDM4E (0.51) | MAPTMAPK1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL14471138 | 0.76 | PPARG (0.51) | ALDH1A1HSD17B10KDM4EPPARGPPARD | |
| SCHEMBL955509 | 0.75 | CYP1A1 (0.46) | MAPTALDH1A1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL22748931 | 0.75 | MAPT (0.48) | MAPTMAPK1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL30029803 | 0.75 | MAPT (0.48) | MAPTMAPK1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL17088080 | 0.74 | ALDH1A1 (0.52) | MAPTALDH1A1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL8957741 | 0.74 | ALDH1A1 (0.54) | MAPTMAPK1NPSR1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |