Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PNLIP | P16233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19266048 | 0.87 | MAPT (0.57) | MAPTNPSR1MAPK1KMT2AHTR2C | |
| SCHEMBL10288034 | 0.82 | IRAK4 (0.49) | MAPTNPSR1MAPK1L3MBTL1KMT2A | |
| SCHEMBL1758548 | 0.79 | KMT2A (0.57) | MAPTNPSR1MAPK1L3MBTL1KMT2A | |
| SCHEMBL19980331 | 0.78 | MAPT (0.66) | MAPTNPSR1MAPK1PKMKMT2A | |
| SCHEMBL23486741 | 0.78 | MAPT (0.47) | MAPTNPSR1MAPK1L3MBTL1KMT2A | |
| SCHEMBL8957741 | 0.78 | ALDH1A1 (0.54) | MAPTNPSR1MAPK1PKMKMT2A | |
| SCHEMBL14785176 | 0.78 | KMT2A (0.56) | MAPTPKML3MBTL1KMT2AHTR2C | |
| SCHEMBL30304115 | 0.78 | KMT2A (0.56) | MAPTPKML3MBTL1KMT2AHTR2C | |
| SCHEMBL20344525 | 0.77 | MAPT (0.50) | MAPTNPSR1MAPK1L3MBTL1KMT2A | |
| SCHEMBL11432026 | 0.77 | KDM4E (0.45) | MAPTNPSR1MAPK1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |