Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980139 | 0.79 | CSNK2A1 (0.40) | CYP19A1SMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL22048701 | 0.79 | KMT2A (0.47) | SMN1; SMN2MAPTALDH1A1POLBKDM4E | |
| SCHEMBL19980436 | 0.79 | HTR2C (0.41) | CYP19A1MAPTALDH1A1POLBKDM4E | |
| SCHEMBL20344564 | 0.77 | CYP19A1 (0.35) | CYP19A1MAPTALDH1A1POLBKDM4E | |
| SCHEMBL21156315 | 0.77 | ALDH1A1 (0.35) | CYP19A1MAPTTHRATHRBSLC6A4 | |
| SCHEMBL19655565 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2MAPTALDH1A1MEN1GAA | |
| SCHEMBL13995380 | 0.74 | CSNK2A1 (0.54) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL16651676 | 0.74 | EPAS1 (0.47) | CYP19A1SMN1; SMN2S1PR3CA12CA1 | |
| SCHEMBL20344535 | 0.74 | CYP1A2 (0.44) | MAPTTHRATHRBALDH1A1POLB | |
| SCHEMBL23337336 | 0.72 | HPGD (0.33) | CYP19A1MAPTALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |