Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 16/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30343464 | 0.87 | CYP1A2 (0.47) | CYP1A2CYP1B1 | |
| SCHEMBL19980414 | 0.87 | CYP1A2 (0.47) | CYP1A2CYP1B1 | |
| SCHEMBL19980463 | 0.85 | MAOA (0.33) | MAOAMAOB | |
| SCHEMBL21113542 | 0.81 | CYP11B1 (0.32) | — | |
| SCHEMBL19980424 | 0.80 | MAPK1 (0.39) | CYP1A2MAOAMAOB | |
| SCHEMBL19567028 | 0.80 | MAPK1 (0.39) | CYP1A2MAOAMAOB | |
| SCHEMBL30322774 | 0.79 | MAOA (0.47) | CYP1A2MAOAMAOB | |
| SCHEMBL19009210 | 0.79 | MAOA (0.47) | CYP1A2MAOAMAOB | |
| SCHEMBL19980425 | 0.78 | CYP1A2 (0.48) | CYP1A2CYP1B1 | |
| SCHEMBL19980421 | 0.78 | CYP1A2 (0.41) | CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512841-B1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2023-04-26 | — | — | EP | disclosed |
| US-11447464-B2 | Compounds with spirobifluorene-structures | MERCK PATENT GMBH (DE) | 2022-09-20 | — | — | US | disclosed |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-06-27 | — | — | US | disclosed |
| WO-2018050584-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447464-B2 | Compounds with spirobifluorene-structures | SLCO1B3, SLCO4C1, SLCO1B1 | CYP1A2 787/4885CYP1B1 880/4885SLC22A12 93/4885 |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | SLCO1B3, SLCO4C1, SLCO1B1 | CYP1A2 787/4885CYP1B1 880/4885SLC22A12 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.