Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 11/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980414 | 0.84 | CYP1A2 (0.47) | CYP1A2CYP1B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL30343464 | 0.84 | CYP1A2 (0.47) | CYP1A2CYP1B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL19980421 | 0.84 | CYP1A2 (0.41) | CYP1A2CYP1B1KMT2AHTTTDP2 | |
| SCHEMBL21110617 | 0.81 | PDK2 (0.40) | CYP1A2PDK2KMT2ACYP2C19 | |
| SCHEMBL19980438 | 0.80 | PDK2 (0.43) | CYP1A2PDK2KMT2ACYP2C19HTT | |
| SCHEMBL19980422 | 0.78 | CYP1A2 (0.41) | CYP1A2CYP1B1 | |
| SCHEMBL30322608 | 0.77 | PDK2 (0.56) | CYP1A2PDK2KMT2ACYP2C19PTPRC | |
| SCHEMBL11990868 | 0.77 | PDK2 (0.56) | CYP1A2PDK2KMT2ACYP2C19PTPRC | |
| SCHEMBL16547425 | 0.76 | PDK2 (0.39) | CYP1A2PDK2KMT2ACYP2C19PTPRC | |
| SCHEMBL32682807 | 0.75 | PDK2 (0.49) | CYP1A2PDK2KMT2ACYP2C19PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512841-B1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2023-04-26 | — | — | EP | disclosed |
| US-11447464-B2 | Compounds with spirobifluorene-structures | MERCK PATENT GMBH (DE) | 2022-09-20 | — | — | US | disclosed |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-06-27 | — | — | US | disclosed |
| WO-2018050584-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447464-B2 | Compounds with spirobifluorene-structures | SLCO1B3, SLCO4C1, SLCO1B1 | CYP1A2 787/4885CYP1B1 880/4885PDK2 835/4885 |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | SLCO1B3, SLCO4C1, SLCO1B1 | CYP1A2 787/4885CYP1B1 880/4885PDK2 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.