Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16566390 | 0.73 | SMYD3 (0.57) | SMYD3KLKB1BAZ2BUSP30BRD4 | |
| SCHEMBL18377475 | 0.71 | KLKB1 (0.56) | KLKB1RIPK1USP30BRD4 | |
| SCHEMBL5730751 | 0.71 | SMYD3 (0.43) | SMYD3KLKB1BAZ2BUSP30BRD4 | |
| SCHEMBL19017622 | 0.70 | USP30 (0.55) | SMYD3BAZ2BUSP30BRD4 | |
| SCHEMBL9714265 | 0.68 | RIPK1 (0.42) | SMYD3KLKB1RIPK1 | |
| SCHEMBL5660505 | 0.67 | MLNR (0.40) | SMYD3KLKB1 | |
| SCHEMBL29335617 | 0.67 | BRD4 (0.43) | BRD4 | |
| SCHEMBL1662858 | 0.64 | BAZ2B (0.46) | SMYD3BAZ2BBRD4 | |
| SCHEMBL7998248 | 0.63 | KLKB1 (0.35) | SMYD3KLKB1 | |
| SCHEMBL7994180 | 0.63 | KLKB1 (0.39) | SMYD3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |