Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714339 | 0.87 | RIPK1 (0.41) | RIPK1CA5AKLKB1SCDSMYD3 | |
| SCHEMBL9714332 | 0.87 | KLKB1 (0.44) | RIPK1CA5AKLKB1SMYD3CYP2C19 | |
| SCHEMBL10568102 | 0.84 | MEN1 (0.46) | RIPK1CA5AKLKB1SCDJAK2 | |
| SCHEMBL12179543 | 0.83 | CA5A (0.46) | RIPK1CA5AKLKB1KDM5B | |
| SCHEMBL9714146 | 0.82 | CA5A (0.58) | RIPK1CA5AKLKB1JAK2JAK1 | |
| SCHEMBL10568262 | 0.79 | ALDH1A1 (0.48) | CA5AGAA | |
| SCHEMBL18377475 | 0.79 | KLKB1 (0.56) | RIPK1KLKB1SCDCYP2C19KDM5B | |
| SCHEMBL21316959 | 0.77 | PTGS1 (0.53) | — | |
| SCHEMBL21316963 | 0.76 | POLB (0.41) | KLKB1GAACYP2C19 | |
| SCHEMBL15838648 | 0.76 | CA5A (0.69) | CA5AKLKB1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | claimed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | claimed |
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |