Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13363552 | 0.79 | ALDH1A1 (0.53) | PNMTALDH1A1NPC1RAB9APLA2G1B | |
| SCHEMBL3047970 | 0.78 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9APLA2G1BATG4B | |
| SCHEMBL19981887 | 0.78 | PNMT (0.44) | PNMTALDH1A1NPC1RAB9APLA2G1B | |
| SCHEMBL13303504 | 0.77 | ALDH1A1 (0.35) | ALDH1A1NPC1RAB9APLA2G1BATG4B | |
| SCHEMBL12024895 | 0.77 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9APLA2G1BATG4B | |
| SCHEMBL12044708 | 0.77 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL31564255 | 0.76 | PNMT (0.43) | PNMTALDH1A1KDM4EMAPT | |
| SCHEMBL17970202 | 0.75 | ALDH1A1 (0.46) | PNMTALDH1A1NPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL31564547 | 0.74 | PNMT (0.41) | PNMTALDH1A1NPC1RAB9APKM | |
| SCHEMBL31564371 | 0.70 | PNMT (0.35) | PNMTALDH1A1NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |