Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461586 | 0.81 | BTK (0.51) | CDK4CDK6BTKHDAC2HDAC1 | |
| SCHEMBL2493454 | 0.72 | BTK (0.53) | CDK4CDK6BTK | |
| SCHEMBL19981710 | 0.72 | BTK (0.36) | CDK4CDK6BTK | |
| SCHEMBL2493665 | 0.71 | BTK (0.60) | CDK4CDK6BTKHDAC2HDAC1 | |
| SCHEMBL2462693 | 0.68 | BTK (0.47) | CDK4CDK6BTKHDAC2HDAC3 | |
| SCHEMBL19981660 | 0.66 | BTK (0.51) | CDK4BTK | |
| SCHEMBL19981771 | 0.65 | BTK (0.50) | BTK | |
| SCHEMBL19981864 | 0.64 | BTK (0.49) | BTK | |
| SCHEMBL19981684 | 0.64 | BTK (0.51) | BTK | |
| SCHEMBL1393056 | 0.64 | CDK4 (0.43) | CDK4CDK6BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |