Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.36 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
| ▸ | BMX | P51813 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461586 | 0.84 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL2493454 | 0.83 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL2493665 | 0.73 | BTK (0.60) | BTKFGRSRCTECBMX | |
| SCHEMBL19981698 | 0.72 | CDK4 (0.36) | BTKCDK4CDK6 | |
| SCHEMBL2495235 | 0.70 | BTK (0.52) | BTKFGRSRCTECBMX | |
| SCHEMBL2462097 | 0.69 | BTK (0.52) | BTKFGRSRCTECBMX | |
| SCHEMBL19971531 | 0.69 | BTK (0.40) | BTKFGRSRCTECBMX | |
| SCHEMBL2495237 | 0.68 | BTK (0.52) | BTKFGRSRCTECBMX | |
| SCHEMBL9984681 | 0.67 | BTK (0.55) | BTKFGRSRCTECBMX | |
| SCHEMBL2490839 | 0.66 | BTK (0.53) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |