Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | FGR | P09769 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | TEC | P42680 | 1/20 | 0.32 |
| ▸ | BMX | P51813 | 1/20 | 0.32 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981722 | 0.81 | BTK (0.46) | BTKBCL6FGRSRCTEC | |
| SCHEMBL2467544 | 0.80 | BTK (0.62) | BTKBCL6HDAC1TMIGD3ADORA1 | |
| SCHEMBL9985071 | 0.76 | BTK (0.41) | BTKBCL6HDAC1TMIGD3ADORA1 | |
| SCHEMBL2461953 | 0.73 | BTK (0.66) | BTKBCL6HDAC1TMIGD3ADORA1 | |
| SCHEMBL2461862 | 0.71 | BTK (0.67) | BTKBCL6FGRSRCTEC | |
| SCHEMBL2491555 | 0.68 | BTK (0.64) | BTKBCL6FGRSRCTEC | |
| SCHEMBL2462150 | 0.68 | BTK (0.64) | BTKBCL6FGRSRCTEC | |
| SCHEMBL2462161 | 0.66 | BTK (0.63) | BTKBCL6HDAC1TMIGD3ADORA1 | |
| SCHEMBL2519798 | 0.66 | BTK (0.58) | BTKBCL6HDAC1TMIGD3ADORA1 | |
| SCHEMBL2463870 | 0.65 | BTK (0.61) | BTKBCL6HDAC1TMIGD3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |