SCHEMBL2459433 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	BTK	Q06187	12/20	0.54

▸	FGR	P09769	1/20	0.54

▸	SRC	P12931	1/20	0.54

▸	TEC	P42680	1/20	0.54

▸	BMX	P51813	1/20	0.54

▸	CCND1	P24385	4/20	0.40

▸	CDK6	Q00534	4/20	0.40

▸	CDK4	P11802	2/20	0.38

▸	CCND3	P30281	2/20	0.37

▸	CCNE2	O96020	1/20	0.37

▸	CDK2	P24941	1/20	0.37

▸	BCL6	P41182	1/20	0.37

▸	CCR1	P32246	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9984681	0.84	BTK (0.55)	BTKFGRSRCTECBMX
SCHEMBL2466505	0.80	BTK (0.65)	BTKFGRSRCTECBMX
SCHEMBL2461862	0.80	BTK (0.67)	BTKFGRSRCTECBMX
SCHEMBL2463009	0.77	BTK (0.49)	BTKFGRSRCTECBMX
SCHEMBL2491727	0.75	BTK (0.64)	BTKFGRSRCTECBMX
SCHEMBL2464916	0.74	BTK (0.70)	BTKFGRSRCTECBMX
SCHEMBL2491884	0.73	BTK (0.64)	BTKFGRSRCTECBMX
SCHEMBL2462218	0.73	BTK (0.64)	BTKFGRSRCTECBMX
SCHEMBL2461953	0.72	BTK (0.66)	BTKFGRSRCTECBMX
SCHEMBL19981722	0.72	BTK (0.46)	BTKFGRSRCTECBMX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2365970-A1	Pyridazinones and their use as btk inhibitors	CGI Pharmaceuticals, Inc. (US)	2011-09-21	—	—	EP	claimed
WO-2010056875-A1	PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS	CGI PHARMACEUTICALS, INC. (US)	2010-05-20	—	—	WO	claimed