Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23920461 | 0.93 | LMNA (0.37) | MEN1CYP3A4ALOX15KMT2ALMNA | |
| SCHEMBL22641327 | 0.89 | CES2 (0.39) | MEN1CYP3A4ALOX15KMT2A | |
| SCHEMBL21686422 | 0.80 | MEN1 (0.36) | MEN1CYP3A4ALOX15KMT2ALMNA | |
| SCHEMBL18848909 | 0.79 | LMNA (0.40) | MEN1CYP3A4ALOX15KMT2ALMNA | |
| SCHEMBL24205737 | 0.79 | MEN1 (0.38) | MEN1CYP3A4ALOX15KMT2ALMNA | |
| SCHEMBL22986016 | 0.78 | CES2 (0.33) | MEN1KMT2ALMNA | |
| SCHEMBL22305025 | 0.77 | LMNA (0.39) | MEN1CYP3A4ALOX15KMT2ALMNA | |
| SCHEMBL27260463 | 0.77 | LMNA (0.39) | MEN1CYP3A4ALOX15KMT2ALMNA | |
| SCHEMBL18482581 | 0.77 | — | — | |
| SCHEMBL24118556 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |