Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 13/20 | 0.85 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982212 | 1.00 | YAP1 (0.85) | YAP1GAAGPR119MEN1POLB | |
| SCHEMBL19982071 | 0.92 | YAP1 (1.00) | YAP1GAAMAPTMAPK1NPSR1 | |
| SCHEMBL19982220 | 0.91 | YAP1 (0.77) | YAP1KMT2ANPSR1 | |
| SCHEMBL19982219 | 0.91 | YAP1 (0.77) | YAP1KMT2ANPSR1 | |
| SCHEMBL19976383 | 0.87 | YAP1 (0.69) | YAP1GAAPOLB | |
| SCHEMBL19976384 | 0.87 | YAP1 (0.69) | YAP1GAAPOLB | |
| SCHEMBL25754096 | 0.86 | YAP1 (0.79) | YAP1GPR119 | |
| SCHEMBL23296230 | 0.84 | YAP1 (1.00) | YAP1 | |
| SCHEMBL19982075 | 0.84 | YAP1 (1.00) | YAP1 | |
| SCHEMBL19982082 | 0.84 | YAP1 (0.62) | YAP1GAAMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |