Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 10/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982105 | 0.84 | YAP1 (0.56) | YAP1GRIN2B | |
| SCHEMBL19982103 | 0.82 | YAP1 (0.57) | YAP1HRH3 | |
| SCHEMBL19974601 | 0.81 | YAP1 (0.54) | YAP1OPRD1GRIN1GRIN2BCCR3 | |
| SCHEMBL21366290 | 0.80 | YAP1 (0.69) | YAP1OPRD1 | |
| SCHEMBL21366289 | 0.80 | YAP1 (0.69) | YAP1OPRD1 | |
| SCHEMBL21366352 | 0.79 | YAP1 (0.67) | YAP1OPRD1 | |
| SCHEMBL21366351 | 0.79 | YAP1 (0.67) | YAP1OPRD1 | |
| SCHEMBL30117577 | 0.79 | YAP1 (0.79) | YAP1 | |
| SCHEMBL19982266 | 0.79 | YAP1 (0.79) | YAP1 | |
| SCHEMBL23339258 | 0.78 | YAP1 (0.69) | YAP1OPRD1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |