Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 12/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982105 | 0.86 | YAP1 (0.56) | YAP1ALDH1A1KMT2A | |
| SCHEMBL19982254 | 0.82 | YAP1 (0.57) | YAP1HRH3 | |
| SCHEMBL19974607 | 0.81 | YAP1 (0.54) | YAP1KDM1A | |
| SCHEMBL19982148 | 0.80 | YAP1 (0.51) | YAP1KDM1A | |
| SCHEMBL19982111 | 0.78 | YAP1 (0.81) | YAP1 | |
| SCHEMBL19982110 | 0.78 | YAP1 (0.81) | YAP1 | |
| SCHEMBL23296224 | 0.77 | YAP1 (0.75) | YAP1ALDH1A1TSHRKMT2A | |
| SCHEMBL19982259 | 0.77 | YAP1 (0.82) | YAP1 | |
| SCHEMBL19982260 | 0.77 | YAP1 (0.82) | YAP1 | |
| SCHEMBL19974553 | 0.77 | YAP1 (0.75) | YAP1ALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |