Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20111170 | 0.80 | TLR4 (0.42) | TLR4MAPK1ABCC1L3MBTL1GAA | |
| SCHEMBL19982604 | 0.80 | HPGD (0.33) | L3MBTL1LMNAALDH1A1KMT2A | |
| SCHEMBL19982403 | 0.78 | TLR4 (0.38) | TLR4MAPK1ABCC1CACNA1DL3MBTL1 | |
| SCHEMBL19982406 | 0.74 | TSHR (0.33) | MAPK1CACNA1DGAALMNAALDH1A1 | |
| SCHEMBL19982574 | 0.71 | TLR4 (0.38) | TLR4L3MBTL1LMNAALDH1A1MAPT | |
| SCHEMBL20111171 | 0.71 | KMT2A (0.37) | TLR4MAPK1CACNA1DL3MBTL1LMNA | |
| SCHEMBL20111191 | 0.71 | KMT2A (0.37) | TLR4MAPK1CACNA1DL3MBTL1LMNA | |
| SCHEMBL20111184 | 0.71 | KMT2A (0.37) | TLR4MAPK1CACNA1DL3MBTL1LMNA | |
| SCHEMBL1864414 | 0.71 | TLR4 (0.46) | TLR4L3MBTL1GAALMNAALDH1A1 | |
| SCHEMBL1869580 | 0.70 | TLR4 (0.53) | TLR4MAPK1L3MBTL1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3296296-A1 | CYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-03-21 | — | — | EP | disclosed |