Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982521 | 0.81 | TLR4 (0.41) | TLR4L3MBTL1SMN1; SMN2 | |
| SCHEMBL19982519 | 0.81 | TLR4 (0.41) | TLR4L3MBTL1SMN1; SMN2 | |
| SCHEMBL20111170 | 0.79 | TLR4 (0.42) | TLR4L3MBTL1MAPK1ABCC1SIRT3 | |
| SCHEMBL19982571 | 0.79 | TLR4 (0.35) | TLR4 | |
| SCHEMBL19982402 | 0.78 | TLR4 (0.36) | TLR4L3MBTL1MAPK1ABCC1SIRT3 | |
| SCHEMBL19982575 | 0.77 | L3MBTL1 (0.31) | L3MBTL1 | |
| SCHEMBL19982456 | 0.74 | TLR4 (0.39) | TLR4L3MBTL1SMN1; SMN2SLC5A2 | |
| SCHEMBL19982454 | 0.74 | TLR4 (0.39) | TLR4L3MBTL1SMN1; SMN2SLC5A2 | |
| SCHEMBL19982560 | 0.74 | TLR4 (0.41) | TLR4L3MBTL1KMT2ASMN1; SMN2GAA | |
| SCHEMBL19982407 | 0.72 | MAPT (0.36) | L3MBTL1MAPK1MEN1KMT2ACACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3296296-A1 | CYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-03-21 | — | — | EP | disclosed |